PLA2G7 Genotype, Lipoprotein-Associated Phospholipase A2 Activity, and Coronary Heart Disease Risk in 10 494 Cases and 15 624 Controls of European Ancestry

• Published in: Circulation (New York, N.Y.) Vol. 121; no. 21; pp. 2284 - 2293
• Main Authors: CASAS, Juan P, NINIO, Ewa, TZOULAKI, Ioanna, KUMARI, Meena, BRUNNER, Eric J, KIVIMAKI, Mika, MARMOT, Michael G, HOFFMANN, Michael M, WINKLER, Karl, MÄRZ, Winfred, YE, Shu, STIMADEL, Heide A, PANAYIOTOU, Andrie, KHAW, Kay-Tee, HUMPHRIES, Steve E, SANDHU, Manjinder S, HINGORANI, Aroon D, TALMUD, Philippa J, PALMEN, Jutta, COOPER, Jackie A, RICKETTS, Sally L, SOFAT, Reecha, NICOLAIDES, Andrew N, CORSETTI, James P, FOWKES, F. Gerry R
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.06.2010
• Subjects: 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Case-Control Studies; Coronary Disease - enzymology; Coronary Disease - epidemiology; Coronary Disease - genetics; Coronary heart disease; Cross-Sectional Studies; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Europe; Genotype; Heart; Humans; Medical sciences; Phospholipases A2 - genetics; Polymorphism, Single Nucleotide - genetics; Prospective Studies; Risk Factors; Europe; risk factors; Enzyme; Genotype; Cardiovascular disease; Esterases; Lipoprotein; mendelian randomization analysis; Coronary heart disease; Epidemiology; Phospholipase A; Carboxylic ester hydrolases; Randomization; genetics; Risk factor; Hydrolases

Higher lipoprotein-associated phospholipase A(2)(Lp-PLA2) activity is associated with increased risk of coronary heart disease (CHD), making Lp-PLA2 a potential therapeutic target. PLA2G7 variants associated with Lp-PLA2 activity could evaluate whether this relationship is causal. A meta-analysis in...