Percutaneous Closure of Patent Foramen Ovale in Patients With Migraine: The PREMIUM Trial

• Published in: Journal of the American College of Cardiology Vol. 70; no. 22; p. 2766
• Main Authors: Tobis, Jonathan M, Charles, Andrew, Silberstein, Stephen D, Sorensen, Sherman, Maini, Brijeshwar, Horwitz, Phillip A, Gurley, John C
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 05.12.2017
• Subjects: Adult; Cardiac Catheterization - methods; Cardiology; Catheterization; Double-Blind Method; Double-blind studies; Echocardiography, Doppler - methods; Female; Fibrillation; Foramen Ovale, Patent - complications; Foramen Ovale, Patent - diagnosis; Foramen Ovale, Patent - surgery; Headache; Headaches; Humans; Hypotheses; Intubation; Male; Medical equipment; Middle Aged; Migraine; Migraine Disorders - complications; Migraine Disorders - diagnosis; Migraine Disorders - physiopathology; Migraine Disorders - therapy; Pain Management - methods; Pain Measurement - methods; Performance evaluation; Prosthesis Implantation - adverse effects; Prosthesis Implantation - instrumentation; Prosthesis Implantation - methods; Remission; Septal Occluder Device; Severity of Illness Index; Treatment Outcome; Ultrasound; double-blind randomized clinical trial; patent foramen ovale; migraine; Amplatzer PFO Occluder device; aura

Migraine is a prevalent and disabling disorder. Patent foramen ovale (PFO) has been associated with migraine, but its role in the disorder remains poorly understood. This study examined the efficacy of percutaneous PFO closure as a therapy for migraine with or without aura. The PREMIUM (Prospective,...