Hyperfractionated Accelerated Radiotherapy versus Conventional Fractionation Both Combined with Chemotherapy in Patients with Locally Advanced Head and Neck Carcinomas: A Retrospective Analysis of a Monoinstitutional Series

• Published in: Oncology Vol. 76; no. 6; pp. 405 - 412
• Main Authors: WELZ, Hanna, POTTGEN, Christoph, STUSCHKE, Martin, JAWAD, Jehad Abu, WIERLEMANN, Arne, WITTIG, Andrea, STÜBEN, Georg, BUDACH, Volker, LEHNERDT, Goetz, JAHNK, Klaus, SACK, Horst
• Format: Journal Article
• Language: English
• Published: Basel Karger 01.01.2009
• Subjects: Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Carcinoma - drug therapy; Carcinoma - radiotherapy; Combined Modality Therapy - methods; Dose Fractionation; Female; Fluorouracil - administration & dosage; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - radiotherapy; Humans; Male; Medical sciences; Middle Aged; Mitomycin - administration & dosage; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Regression Analysis; Retrospective Studies; Treatment Outcome; Tumors; Antineoplastic agent; 5-Fluorouracil; Cancerology; ENT disease; Mitomycin C; Head and neck carcinoma; Accelerated radiotherapy; Fluorouracil; Human; Drug combination; Fractionation; Mitomycin; Enzyme; Fluoropyrimidine derivatives; Transferases; Enzyme inhibitor; Malignant tumor; Thymidylate synthase; Radiotherapy; Retrospective; Concomitant chemotherapy; Hyperfractionation; Alkylating agent; Chemotherapy; Treatment; Antimetabolic; Methyltransferases; Pyrimidine derivatives; Head and neck cancer; Combined treatment; Locally advanced stage; Comparative study; Cancer

Hyperfractionated accelerated radiotherapy (HART) has been combined with chemotherapy (CC) for locally advanced head and neck cancer, but no data from randomized trials are available for a comparison with conventionally fractionated radiotherapy (CFRT) and CC. This monoinstitutional retrospective st...