Antifungal susceptibilities of dermatophytic agents isolated from clinical specimens

The aim of this study was to investigate the susceptibility to four antifungal agents: ketoconazole, terbinafine, itraconazole and fluconazole, of the different species of dermatophyte strains isolated from clinical specimens. A total of 128 specimens were collected from toe nail, foot, inguinal reg...

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Bibliographic Details
Published inEJD. European journal of dermatology Vol. 15; no. 4; p. 258
Main Authors Cetinkaya, Zafer, Kiraz, Nuri, Karaca, Semsettin, Kulac, Mustafa, Ciftci, Ihsan H, Aktepe, Orhan C, Altindis, Mustafa, Kiyildi, Nilay, Piyade, Meltem
Format Journal Article
LanguageEnglish
Published France 01.07.2005
Subjects
Administration, Cutaneous
Antifungal Agents - administration & dosage
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Arthrodermataceae - drug effects
Dermatomycoses - drug therapy
Dermatomycoses - microbiology
Fluconazole - administration & dosage
Fluconazole - pharmacology
Fluconazole - therapeutic use
Humans
Itraconazole - administration & dosage
Itraconazole - pharmacology
Itraconazole - therapeutic use
Ketoconazole - administration & dosage
Ketoconazole - pharmacology
Ketoconazole - therapeutic use
Microbial Sensitivity Tests
Naphthalenes - administration & dosage
Naphthalenes - pharmacology
Naphthalenes - therapeutic use
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Summary:The aim of this study was to investigate the susceptibility to four antifungal agents: ketoconazole, terbinafine, itraconazole and fluconazole, of the different species of dermatophyte strains isolated from clinical specimens. A total of 128 specimens were collected from toe nail, foot, inguinal region, trunk, hands and head. The dermatophytes tested included Trichophyton rubrum 108 (84.4%), Trichophyton mentagrophytes 11 (8.6%), Epidermophyton floccosum 5 (3.9%), Microsporum canis 2 (1.5%) and Trichophyton tonsurans 2 (1.5%). The mean minimum inhibitory concentrations (MIC) for the five species of dermatophytes ranged between 0.09-1.12 microg/mL for ketoconazole, 0.04-0.27 microg/mL for terbinafine, 0.08-0.43 microg/mL for itraconazole and 16.18-24.0 microg/mL for fluconazole. In vitro analysis of antifungal activity of these agents would also allow for the comparison between different systemic antifungals, which in turn may clarify the reasons for the lack of clinical response or serve as an effective therapy for patients with chronic infection.
ISSN:1167-1122