Genetic polymorphisms of glutathione S-transferases and disease activity of rheumatoid arthritis

• Published in: Clinical and experimental rheumatology Vol. 27; no. 2; pp. 229 - 236
• Main Authors: BOHANEC GRABAR, P, LOGAR, D, TOMSIC, M, ROZMAN, B, DOLZAN, V
• Format: Journal Article
• Language: English
• Published: Pisa Clinical and Experimental Rheumatology 01.03.2009
• Subjects: Aged; Arthritis, Rheumatoid - genetics; Biological and medical sciences; Diseases of the osteoarticular system; Female; Genotype; Glutathione S-Transferase pi - genetics; Glutathione Transferase - genetics; Humans; Inflammatory joint diseases; Male; Medical sciences; Middle Aged; Polymorphism, Single Nucleotide; Severity of Illness Index; Smoking - adverse effects; Smoking - genetics; Tobacco, tobacco smoking; Toxicology; Immunopathology; Disease activity; Enzyme; Activity index; Transferases; Diseases of the osteoarticular system; Rheumatology; Tobacco smoking; Autoimmune disease; Inflammatory joint disease; Chronic; GST polymorphism; Glutathione transferase; Rheumatoid arthritis; smoking; Genetics; Polymorphism

Glutathione S-transferases (GST); GST-mu1 (GSTM1), GST-pi1 (GSTP1) and GST-theta1 (GSTT1) have peroxidase activity towards cytotoxic metabolites produced in inflammatory reactions, the main feature of rheumatoid arthritis (RA). Genetic polymorphisms in GSTM1, GSTP1 and GSTT1 modify the enzyme conjug...