Fast inactivation of voltage-dependent calcium channels. A hinged-lid mechanism?

• Published in: The Journal of biological chemistry Vol. 275; no. 32; pp. 24575 - 24582
• Main Authors: Stotz, S C, Hamid, J, Spaetgens, R L, Jarvis, S E, Zamponi, G W
• Format: Journal Article
• Language: English
• Published: United States 11.08.2000
• Subjects: Animals; Brain - metabolism; Calcium Channels - chemistry; Calcium Channels - drug effects; Calcium Channels - physiology; Cell Line; Egtazic Acid - pharmacology; Humans; Kidney; Macromolecular Substances; Membrane Potentials - physiology; Models, Molecular; Protein Structure, Secondary; Rats; Recombinant Fusion Proteins - chemistry; Recombinant Fusion Proteins - drug effects; Recombinant Fusion Proteins - metabolism; Tetraethylammonium - pharmacology

We recently described domains II and III as important determinants of fast, voltage-dependent inactivation of R-type calcium channels (Spaetgens, R. L., and Zamponi, G. W. (1999) J. Biol. Chem. 274, 22428-22438). Here we examine in greater detail the structural determinants of inactivation using a s...