The detection of macroprolactin by precipitation and ultrafiltration methods

• Published in: Endokrynologia Polska Vol. 62; no. 6; pp. 529 - 536
• Main Authors: Beda-Maluga, Karolina, Pisarek, Hanna, Komorowski, Jan, Pawlikowski, Marek, Świętosławski, Jacek, Winczyk, Katarzyna
• Format: Journal Article
• Language: English
• Published: Poland Wydawnictwo Via Medica 2011
• Subjects: Adolescent; Adult; Biomarkers - blood; Female; Fractional Precipitation - methods; Humans; Hyperprolactinemia - blood; Hyperprolactinemia - diagnosis; Male; Middle Aged; Pituitary Neoplasms - blood; Pituitary Neoplasms - diagnosis; Polycystic ovary syndrome; Polyethylene glycol; Polyethylene Glycols; Predictive Value of Tests; Prolactin - blood; Prolactinoma - blood; Prolactinoma - diagnosis; Reproducibility of Results; Tumors; Ultrafiltration - methods; Young Adult

Prolactin (PRL) exists in human blood in several molecular forms. Macroprolactin (MaPRL), which most often consists of monomeric PRL and immunoglobulin G, has the highest molecular weight but no biological activity. Immunoassays do not distinguish MaPRL from monomeric PRL, what can lead to an incorr...