Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents

• Published in: Bioorganic & medicinal chemistry Vol. 9; no. 11; pp. 2871 - 2884
• Main Authors: IWASA, Kinuko, MORIYASU, Masataka, TACHIBANA, Yoko, KIM, Hye-Sook, WATAYA, Yusuke, WIEGREBE, Wolfgang, BASTOW, Kenneth F, COSENTINO, L. Mark, KOZUKA, Mutsuo, LEE, Kuo-Hsiung
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Science 01.11.2001
• Subjects: Alkaloids - chemical synthesis; Alkaloids - chemistry; Alkaloids - pharmacology; Animals; Anti-Bacterial Agents; Anti-HIV Agents - chemical synthesis; Anti-HIV Agents - chemistry; Anti-HIV Agents - pharmacology; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimalarials - chemical synthesis; Antimalarials - chemistry; Antimalarials - pharmacology; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological and medical sciences; Candida albicans - drug effects; Cell Division - drug effects; Crystallization; Drug Evaluation, Preclinical; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; HIV-1 - drug effects; Humans; Isoquinolines - chemical synthesis; Isoquinolines - chemistry; Isoquinolines - pharmacology; Magnetic Resonance Spectroscopy; Medical sciences; Mice; Microbial Sensitivity Tests; Miscellaneous. Antibiotics with multiple activities; Pharmacology. Drug treatments; Plasmodium falciparum - drug effects; Structure-Activity Relationship; Tumor Cells, Cultured - drug effects; Antineoplastic agent; Antimalarial; Organic cation; Nitrogen heterocycle; Cytotoxicity; Screening test; Antimicrobial agent; Plasmodium falciparum; Alkaloid; Structure activity relation; Benzylic compound; Parasiticid; Bicyclic compound; Antiviral; Aromatic compound; Chemical synthesis; Protozoa; Apicomplexa; Isoquinoline derivatives; Iminium compounds; Retroviridae; Lentivirus; In vitro; Virus; Phenols; Human immunodeficiency virus

Twenty-six simple isoquinolines and 21 benzylisoquinolines were tested for antimicrobial, antimalarial, cytotoxic, and anti-HIV activities. Some simple isoquinoline alkaloids were significantly active in each assay, and may be useful as lead compounds for developing potential chemotherapeutic agents...