Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: A clinical pilot study

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 11; no. 11; pp. 1459 - 1465
• Main Authors: EL-BAYOUMY, Karam, RICHIE, John P, BOYIRI, Telih, KOMNINOU, Despina, PROKOPCZYK, Bogdan, TRUSHIN, Neil, KLEINMAN, Wayne, COX, Julie, PITTMAN, Brian, COLOSIMO, Steven
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.11.2002
• Subjects: Adult; Biological and medical sciences; Biomarkers - blood; Biomarkers - urine; Creatinine - urine; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - urine; Dietary Supplements; Dihydrotestosterone - blood; Double-Blind Method; Factor IX - drug effects; Glutathione - blood; Glutathione - drug effects; Humans; Male; Medical sciences; Nephrology. Urinary tract diseases; Patient Compliance; Pilot Projects; Prostate-Specific Antigen - blood; Prostate-Specific Antigen - drug effects; Reference Values; Selenium - blood; Selenium - therapeutic use; Time Factors; Treatment Outcome; Tumors of the urinary system; Urinary tract. Prostate gland; Yeast, Dried - therapeutic use; Human; Hormone; Oxidative stress; Urinary system disease; Yeast; Prostate disease; Healthy subject; Biological marker; Male; Malignant tumor; Epidemiology; Prevention; Treatment; Risk factor; Adult; Supplementation; Selenium; Male genital diseases; Prostate

The mechanisms responsible for the protective role of selenium against the development of prostate cancer remain to be determined (L. C. Clark et al., J. Am. Med. Assoc., 276: 1957-1963, 1996). In the present study, we tested the hypothesis that selenium supplementation reduces oxidative stress. A s...