Inhibition of growth of human breast carcinoma cells by an antisense oligonucleotide targeted to the transferrin receptor gene

• Published in: Anticancer research Vol. 21; no. 3B; p. 1777
• Main Authors: Yang, D C, Jiang, X P, Elliott, R L, Head, J F
• Format: Journal Article
• Language: English
• Published: Greece 01.05.2001
• Subjects: Breast Neoplasms - drug therapy; Cell Division; Cell Survival; Deferoxamine - pharmacology; DNA - metabolism; Dose-Response Relationship, Drug; Humans; Hydroxyurea - pharmacology; Immunohistochemistry; Inhibitory Concentration 50; Oligonucleotides, Antisense - pharmacology; Receptors, Transferrin - biosynthesis; Receptors, Transferrin - genetics; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Tumor Cells, Cultured

Transferrin receptor expression is controlled by the amount of iron required by the cell to maintain its metabolism and therefore tumor cells in a highly proliferative state have a high density of transferrin receptors. In this study, phosphorothioated antisense TfR oligonucleotides (TfR-ODna) targe...