Cell-cycle regulation of B-Myb protein expression: specific phosphorylation during the S phase of the cell cycle

• Published in: Oncogene Vol. 12; no. 9; p. 1855
• Main Authors: Robinson, C, Light, Y, Groves, R, Mann, D, Marias, R, Watson, R
• Format: Journal Article
• Language: English
• Published: England 02.05.1996
• Subjects: 3T3 Cells; Animals; Cell Cycle Proteins; Cell Extracts; Cyclin-Dependent Kinases - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Mice; Phosphorylation; S Phase; Trans-Activators; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic

Previous studies revealed that transcription of B-Myb, which encodes a transcription factor related to the c-Myb proto-oncoprotein, is cell-cycle regulated by an E2F transcription factor-mediated repression mechanism operating in G0/G1. To begin to determine the consequences of transcriptional regul...