Effects of free fatty acids on the muscle cell membrane and their possible relations to the depression of contraction

High concentrations of free fatty acids (FFA) depolarize the resting muscle cell membrane and decrease the membrane resistance. In contrast, low concentrations have a "membrane stabilizing effect" which decreases action potential (AP) and voltage-dependent ionic currents. The changes of AP...

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Bibliographic Details
Published inBiomedica biochimica acta Vol. 45; no. 1-2; p. S51
Main Authors Caffier, G, Kössler, F, Küchler, G
Format Journal Article
LanguageEnglish
Published Germany 1986
Subjects
Animals
Caproates - pharmacology
Caprylates - pharmacology
Dose-Response Relationship, Drug
Electric Conductivity
Fatty Acids, Nonesterified - pharmacology
In Vitro Techniques
Ion Channels - drug effects
Membrane Lipids - physiology
Membrane Potentials - drug effects
Muscle Contraction - drug effects
Myocardial Contraction - drug effects
Sarcolemma - drug effects
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Summary:High concentrations of free fatty acids (FFA) depolarize the resting muscle cell membrane and decrease the membrane resistance. In contrast, low concentrations have a "membrane stabilizing effect" which decreases action potential (AP) and voltage-dependent ionic currents. The changes of AP may result in a decrease of excitation-induced Ca++ release from cellular stores. This may be a causal factor for depression of contraction by FFA.
ISSN:0232-766X