Bacteriolytic effect of cessation of glucosamine supply, induced by specific inhibition of glucosamine-6-phosphate synthetase

• Published in: Acta microbiologica Polonica Vol. 35; no. 1-2; p. 15
• Main Authors: Chmara, H, Borowski, E
• Format: Journal Article
• Language: English
• Published: Poland 1986
• Subjects: Anti-Bacterial Agents - pharmacology; Dipeptides - pharmacology; Escherichia coli - drug effects; Escherichia coli - enzymology; Escherichia coli - growth & development; Glucosamine - metabolism; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - antagonists & inhibitors; Kinetics; Penicillin G - pharmacology; Transaminases - antagonists & inhibitors

The antibiotic tetaine (bacilysin) and its C-terminal epoxyaminoacid--anticapsin--are powerful inhibitors of glucosamine-6-phosphate synthetase (EC 5.3.1.19.) in cell-free extracts of Escherichia coli K-12. Tetaine acts on growing cells as a bactericidal agent. This bactericidal action, measured fro...