A new in vivo test method to compare wound dressing fluid handling characteristics and wear time

• Published in: Ostomy/wound management Vol. 57; no. 8; pp. 28 - 36
• Main Authors: Lutz, James B, Zehrer, Cindy L, Solfest, Staci E, Walters, Shelley-Ann
• Format: Journal Article
• Language: English
• Published: United States HMP Communications 01.08.2011
• Subjects: Ambulatory Care Facilities - organization & administration; Bandages; Home Care Services; Humans; Medical supplies; Nursing; Prospective Studies; Wear; Wound healing
• ISSN: 2640-5237; 1943-2720; 2640-5245

A refined in vivo artificial wound model utilizing artificial wound fluid (AWF) was developed to overcome important limitations such as adhesive-skin interactions, movement, pressure, shear, and varying environmental conditions in in vitro models. Using this model, a study with primary endpoints of wear time and fluid handling capacity was conducted to compare two foam dressings: a high performance (HPF) dressing and an adhesive dressing (AAF). A 10-cm(2) artificial wound bed, created using a nonstick absorbent pad, was applied to the lower back of 24 healthy volunteers and the tip of a 23-gauge catheter was inserted into the pad to administer AWF. The pad and catheter were secured in place with paper tape and covered with the test dressings. This model and 1.0-mL AWF infusions every 12 hours was used to simulate highly exudating wounds. The HPF dressing absorbed 75% more fluid before failure and remained intact for a median of 6.1 days compared to 3.5 days for the AAF dressing (P <0.001, Cox proportional hazard model). Comparisons between dressing outcomes using this model and previously published in vitro results suggest the model may be valid and reliable. Studies to ascertain the ability of this model to predict clinical dressing performance and research to compare other wound outcomes that affect dressing change frequency and cost (eg, healing) are needed.