1-[(Benzofuran-2-yl)phenylmethyl]triazoles as steroidogenic inhibitors: synthesis and in vitro inhibition of human placental CYP19 aromatase

• Published in: Anti-cancer drug design Vol. 16; no. 4-5; p. 217
• Main Authors: Vinh, T K, Yee, S W, Kirby, A J, Nicholls, P J, Simons, C
• Format: Journal Article
• Language: English
• Published: United States 01.08.2001
• Subjects: Adult; Animals; Aromatase Inhibitors; Benzofurans - chemical synthesis; Benzofurans - pharmacology; Chromatography, High Pressure Liquid; Enzyme Inhibitors - pharmacology; Estrogens - biosynthesis; Female; Humans; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Microsomes - enzymology; Placenta - drug effects; Placenta - enzymology; Pregnancy; Rats; Steroid 17-alpha-Hydroxylase - metabolism; Steroids - antagonists & inhibitors; Steroids - biosynthesis; Structure-Activity Relationship; Testis - drug effects; Testis - enzymology; Triazoles - chemical synthesis; Triazoles - pharmacology

Hormone-dependent breast cancer is stimulated by the female hormones oestrone and oestradiol, therefore compounds which inhibit the specific enzymes involved in the formation of the nitogenic hormones, namely CYP19 aromatase (P450arom) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type 1, are...