Effect of alcohol on the secretion of tumor necrosis factor-α by macrophages in the presence of rat Serum

• Published in: Alcoholism, clinical and experimental research Vol. 26; no. 8; pp. 81S - 85S
• Main Authors: NAKATANI, Yoshihiro, FUKUI, Hiroshi, KITAZAWA, Toshiyuki, FUJIMOTO, Masao, YAMAO, Junichi, UEMURA, Masahito
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Baltimore, MD Lippincott Williams & Wilkins 01.08.2002
• Subjects: Acute-Phase Proteins; Alcoholism and acute alcohol poisoning; Animals; Biological and medical sciences; Carrier Proteins - physiology; Dose-Response Relationship, Drug; Ethanol - toxicity; Kupffer Cells - immunology; Lipopolysaccharides - immunology; Liver Diseases, Alcoholic - immunology; Macrophages, Alveolar - drug effects; Macrophages, Alveolar - immunology; Macrophages, Peritoneal - drug effects; Macrophages, Peritoneal - immunology; Male; Medical sciences; Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Toxicology; Tumor Necrosis Factor-alpha - secretion; Ethanol; Rat; Pathogenesis; Toxicity; Alcoholism; Rodentia; Hepatic disease; Endotoxin; In vitro; Toxin; Kupffer cell; Binding protein; Vertebrata; Mammalia; Pulmonary alveolus; Animal; Lipopolysaccharide; Tumor necrosis factor α; Macrophage; Peritoneum

It is suggested that endotoxin, proinflammatory cytokines, and lipopolysaccharide-binding protein (LBP) play an important role in the development of alcoholic liver disease. Our previous study showed that splenic macrophages were important for endotoxin uptake and excessive production of tumor necro...