Interaction of Rickettsia prowazekii strains of different virulence with white rat macrophages
The growth of mildly pathogenic strain E, its virulent revertant EVir, and prototype virulent strain Breinl of Rickettsia prowazekii in peritoneal macrophage cultures of outbread white rats (WR) was evaluated by light microscopy and bioassay in chick embryos (CE). Macrophage cultures infected with s...
Saved in:
Published in | Acta virologica (Anglickâa verze) Vol. 39; no. 4; p. 205 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Slovakia
01.09.1995
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | The growth of mildly pathogenic strain E, its virulent revertant EVir, and prototype virulent strain Breinl of Rickettsia prowazekii in peritoneal macrophage cultures of outbread white rats (WR) was evaluated by light microscopy and bioassay in chick embryos (CE). Macrophage cultures infected with strain E were characteristic by limited number of infected cells, poor or moderate accumulation of rickettsiae in individual cells, poor or nil spread of infectious process during first 7 days of infection, and the death of rickettsiae in cultures as determined by the bioassay in CE. Moreover, rickettsiae were not determined in 20.7% of infected macrophage cultures by either microscopic or bioassay methods. In contrast, the growth of virulent strains EVir and Breinl was characteristic by higher proportion of infected cells, considerable accumulation of rickettsiae, and intensive spread of infectious process within 5-7 days post infection (p.i.). However, the intensity of infectious process in macrophage cultures was less expressed with strain EVir than with strain Breinl. |
---|---|
AbstractList | The growth of mildly pathogenic strain E, its virulent revertant EVir, and prototype virulent strain Breinl of Rickettsia prowazekii in peritoneal macrophage cultures of outbread white rats (WR) was evaluated by light microscopy and bioassay in chick embryos (CE). Macrophage cultures infected with strain E were characteristic by limited number of infected cells, poor or moderate accumulation of rickettsiae in individual cells, poor or nil spread of infectious process during first 7 days of infection, and the death of rickettsiae in cultures as determined by the bioassay in CE. Moreover, rickettsiae were not determined in 20.7% of infected macrophage cultures by either microscopic or bioassay methods. In contrast, the growth of virulent strains EVir and Breinl was characteristic by higher proportion of infected cells, considerable accumulation of rickettsiae, and intensive spread of infectious process within 5-7 days post infection (p.i.). However, the intensity of infectious process in macrophage cultures was less expressed with strain EVir than with strain Breinl. |
Author | Ignatovich, V F Balayeva, N M Penkina, G A |
Author_xml | – sequence: 1 givenname: G A surname: Penkina fullname: Penkina, G A organization: Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia – sequence: 2 givenname: V F surname: Ignatovich fullname: Ignatovich, V F – sequence: 3 givenname: N M surname: Balayeva fullname: Balayeva, N M |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8825301$$D View this record in MEDLINE/PubMed |
BookMark | eNotj11LwzAYRoNMZjf9CUL-QCFN0jS7lOHHYCCIgleOt8kbG7emJcks-utV3MXDuTkceBZkFoaAZ6SohFAlF6yekYIxVpUNF68XZJHSB2NS_m5O5lrzWrCqIG-bkDGCyX4IdHD0yZs95pw80DEOE3zj3nuacgQf0p9gvXMYMWT66ePxgMEgnXzu6NT5jDRCpj2YOIwdvGO6JOcODgmvTlySl7vb5_VDuX2836xvtuXIRZNLoStbgzK2aXTFrAHZWmiYclIbQLVarVwrdd1IJ5UCjs5orQCdlW3N0VZ8Sa7_u-Ox7dHuxuh7iF-700_-A_KTVGM |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Biology |
EISSN | 1336-2305 |
ExternalDocumentID | 8825301 |
Genre | Journal Article |
GroupedDBID | --- .GJ 53G 5GY 5RE 6RX 9T4 AAFWJ ABCQX ABOCM ABPPZ AENEX AFFNX AFPKN AKWKQ ALMA_UNASSIGNED_HOLDINGS CGR CUY CVF EBS ECM EIF EJD EMOBN F5P FRP GROUPED_DOAJ NPM SJN ZGI ZXP ~KM |
ID | FETCH-LOGICAL-p237t-381d5a6cd77810dca4bda706f48cae6999fb48574f466a2efc886aefd4b52ed12 |
ISSN | 0001-723X |
IngestDate | Thu May 23 23:01:25 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p237t-381d5a6cd77810dca4bda706f48cae6999fb48574f466a2efc886aefd4b52ed12 |
PMID | 8825301 |
ParticipantIDs | pubmed_primary_8825301 |
PublicationCentury | 1900 |
PublicationDate | 1995-09-01 |
PublicationDateYYYYMMDD | 1995-09-01 |
PublicationDate_xml | – month: 09 year: 1995 text: 1995-09-01 day: 01 |
PublicationDecade | 1990 |
PublicationPlace | Slovakia |
PublicationPlace_xml | – name: Slovakia |
PublicationTitle | Acta virologica (Anglickâa verze) |
PublicationTitleAlternate | Acta Virol |
PublicationYear | 1995 |
SSID | ssj0044004 |
Score | 1.4306657 |
Snippet | The growth of mildly pathogenic strain E, its virulent revertant EVir, and prototype virulent strain Breinl of Rickettsia prowazekii in peritoneal macrophage... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 205 |
SubjectTerms | Animals Cells, Cultured Chick Embryo Macrophages, Peritoneal - metabolism Macrophages, Peritoneal - microbiology Male Rats Rickettsia prowazekii - growth & development Rickettsia prowazekii - pathogenicity Time Factors Virulence |
Title | Interaction of Rickettsia prowazekii strains of different virulence with white rat macrophages |
URI | https://www.ncbi.nlm.nih.gov/pubmed/8825301 |
Volume | 39 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ3NT9swFMCtwoTEBcE2ND7lw26Vp8ax43AsiM9DtQNMnAZ2bG_RRqkggOhfz3u2aSK0IbZLVMVuU-Vnv7z38j4I-WysxKIwig202WHCZYaV3JfMWSN3bOmrMgbIjoqjM3FyLs97vctO1NJdY75U0z_mlfwPVTgHXDFL9h_Izn4UTsBn4AtHIAzHNzEO7rzU7BuLitSwJZvmttYYdvWgp-5XXWM2iK5jsNtzN5Smf1_f3IV0o-iIfcCXCX1YDP0rjT29foKUue3qrcOq0filJCpRLx1iAjAIU3zTzmHQ3Uxdx6_w1WFThqCaHrYO0-MfY7DyQToFb863Nq54V__Wj-4-zB8lF61N2XlyFm3VCtiMKR5a_MLjJcrUPC8YWDqyK3RjBaO0uERXgsZ5HXqTq4APTAGZx2u9OviifHYamSNzqkQJOEJvTnxSC5Rf0TyKf3qRLKTpL4yMoGycLpOlZCXQYUS-Qnpu_J4sxL6hjx_I9w54eu1pC5624GkCjxNm4OkMPEXwNICnAJ52wH8kZwf7p3tHLDXKYBOeq4aB1mWlLiqrVJkNbKWFsVoNCi_KSrsCbABvRCmV8KIoNHe4AwvtvBVGcmczvkrmx9dj94nQDNuJemV5BnY_lqioOKgzuRHOKp3Jao2sxhtzMYnVUC7SHVv_28AGWWxXyiZ552HzuS3Q5BqzHXA8AahYTcM |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interaction+of+Rickettsia+prowazekii+strains+of+different+virulence+with+white+rat+macrophages&rft.jtitle=Acta+virologica+%28Anglick%C3%A2a+verze%29&rft.au=Penkina%2C+G+A&rft.au=Ignatovich%2C+V+F&rft.au=Balayeva%2C+N+M&rft.date=1995-09-01&rft.issn=0001-723X&rft.eissn=1336-2305&rft.volume=39&rft.issue=4&rft.spage=205&rft_id=info%3Apmid%2F8825301&rft_id=info%3Apmid%2F8825301&rft.externalDocID=8825301 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0001-723X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0001-723X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0001-723X&client=summon |