A new member of the Eph family of receptors that lacks protein tyrosine kinase activity

• Published in: Oncogene Vol. 13; no. 4; p. 777
• Main Authors: Gurniak, C B, Berg, L J
• Format: Journal Article
• Language: English
• Published: England 15.08.1996
• Subjects: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain - metabolism; Chickens; DNA, Complementary; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Molecular Sequence Data; Protein-Tyrosine Kinases - metabolism; Receptor, EphB6; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sequence Homology, Amino Acid; Thymus Gland - metabolism

Using a PCR-based screen to identify tyrosine kinases involved in T cell development, we have cloned a new member of the Eph-family of receptor tyrosine kinases (Mep, for murine eph-family protein). At the amino acid level Mep is 60% identical to the chicken embryonic kinase Cek9. Sequence analysis...