Lack of difference in iron status assessed by soluble transferrin receptor between children with cerebral malaria and those with non-cerebral malaria
We conducted this study to determine whether children with cerebral malaria are less likely to have tissue iron deficiency than those with non-cerebral malaria. Iron status was assessed by soluble transferrin receptor (sTfR), serum ferritin, and haemoglobin in 44 Zaïrian children: 15 with cerebral m...
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Published in | Journal of tropical pediatrics (1980) Vol. 45; no. 3; p. 166 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.06.1999
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Abstract | We conducted this study to determine whether children with cerebral malaria are less likely to have tissue iron deficiency than those with non-cerebral malaria. Iron status was assessed by soluble transferrin receptor (sTfR), serum ferritin, and haemoglobin in 44 Zaïrian children: 15 with cerebral malaria, 14 with non-cerebral malaria, and 15 without malaria (age range 0.5-16 years). Although there was no significant difference in the mean concentrations of sTfR, serum ferritin, or haemoglobin between either group of patients, a higher percentage of children with cerebral malaria (27 per cent) than those with non-cerebral malaria (14 per cent) or controls (7%) had sTfR levels above 7.3 mg/l (suggestive of tissue iron deficiency). A higher percentage of children with cerebral malaria (40 per cent) than with non-cerebral malaria (29 per cent) or controls (20 per cent) also had either serum ferritin < 100 micrograms/l and inflammation or sTfR > 7.3 mg/l or both. The data suggest that children with cerebral malaria are as likely to have tissue iron deficiency as those with non-cerebral malaria. |
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AbstractList | We conducted this study to determine whether children with cerebral malaria are less likely to have tissue iron deficiency than those with non-cerebral malaria. Iron status was assessed by soluble transferrin receptor (sTfR), serum ferritin, and haemoglobin in 44 Zaïrian children: 15 with cerebral malaria, 14 with non-cerebral malaria, and 15 without malaria (age range 0.5-16 years). Although there was no significant difference in the mean concentrations of sTfR, serum ferritin, or haemoglobin between either group of patients, a higher percentage of children with cerebral malaria (27 per cent) than those with non-cerebral malaria (14 per cent) or controls (7%) had sTfR levels above 7.3 mg/l (suggestive of tissue iron deficiency). A higher percentage of children with cerebral malaria (40 per cent) than with non-cerebral malaria (29 per cent) or controls (20 per cent) also had either serum ferritin < 100 micrograms/l and inflammation or sTfR > 7.3 mg/l or both. The data suggest that children with cerebral malaria are as likely to have tissue iron deficiency as those with non-cerebral malaria. |
Author | Yu, L Warrier, R P Ode, D Tshefu, K A Kivibidila, S |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10401196$$D View this record in MEDLINE/PubMed |
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Snippet | We conducted this study to determine whether children with cerebral malaria are less likely to have tissue iron deficiency than those with non-cerebral... |
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SubjectTerms | Adolescent Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - etiology Case-Control Studies Child Child, Preschool Cross-Sectional Studies Female Ferritins - blood Hemoglobins - analysis Humans Infant Inflammation Malaria, Cerebral - complications Malaria, Cerebral - immunology Malaria, Falciparum - complications Malaria, Falciparum - immunology Male Receptors, Transferrin - blood |
Title | Lack of difference in iron status assessed by soluble transferrin receptor between children with cerebral malaria and those with non-cerebral malaria |
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