Normalization of the altered liver function tests after islet transplantation in diabetic rats

• Published in: Diabete & metabolisme Vol. 16; no. 4; p. 284
• Main Authors: Barneo, L, Esteban, M M, Garcia-Pravia, C, Diaz, F, Marin, B
• Format: Journal Article
• Language: English
• Published: France 01.07.1990
• Subjects: Alanine Transaminase - blood; Alkaline Phosphatase - blood; Animals; Aspartate Aminotransferases - blood; Blood Glucose - metabolism; Diabetes Mellitus, Experimental - pathology; Diabetes Mellitus, Experimental - physiopathology; Diabetes Mellitus, Experimental - surgery; Female; Glycogen - metabolism; Islets of Langerhans Transplantation; Liver - pathology; Liver - physiopathology; Male; Microscopy, Electron; Rats; Rats, Inbred Strains

The purpose of our study was to determine if streptozotocin induced diabetes (SID) in rats produces alterations in hepatic function, as described in poorly controlled diabetic patients, and if islet transplantation (islet-Tx) would subsequently ameliorate this status. Hepatocellular dysfunction was...