A double-blind crossover comparison of flecainide and slow-release mexiletine in the treatment of stable premature ventricular complexes

• Published in: International journal of clinical pharmacology research Vol. 11; no. 1; p. 23
• Main Authors: Capucci, A, Di Pasquale, G, Boriani, G, Carini, G, Balducelli, M, Frabetti, L, Carozzi, A, Finzi, A, Pinelli, G, Magnani, B
• Format: Journal Article
• Language: English
• Published: Switzerland 1991
• Subjects: Cardiac Complexes, Premature - drug therapy; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Female; Flecainide - administration & dosage; Flecainide - adverse effects; Flecainide - therapeutic use; Half-Life; Humans; Male; Mexiletine - administration & dosage; Mexiletine - adverse effects; Mexiletine - therapeutic use; Middle Aged

In 24 patients with stable premature ventricular contractions (PVCs) greater than or equal to 100/h, Lown class greater than or equal to 2 the relative anti-arrhythmic efficacy of flecainide 150 mg twice daily and slow-release mexiletine 360 mg twice daily was evaluated in a double-blind placebo-con...