Porcine kidney microsomal cysteine S-conjugate N-acetyltransferase-catalyzed N-acetylation of haloalkene-derived cysteine S-conjugates

• Published in: Drug metabolism and disposition Vol. 28; no. 4; pp. 440 - 445
• Main Authors: KRAUS, T, UTTAMSINGH, V, ANDERS, M. W, WOLF, S
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 01.04.2000
• Subjects: Acetyl-CoA Hydrolase - metabolism; Acetylation; Acetyltransferases - metabolism; Alkenes - metabolism; Amidohydrolases - metabolism; Animals; Biological and medical sciences; Chemical and industrial products toxicology. Toxic occupational diseases; Cysteine - metabolism; General pharmacology; In Vitro Techniques; Kidney - enzymology; Kinetics; Medical sciences; Microsomes - enzymology; Miscellaneous; Pharmacology. Drug treatments; Swine; Toxicology; Various organic compounds; Urine; Acyltransferases; Cysteine-S-conjugate N-acetyltransferase; Biological fluid; Enzyme; Transferases; Elimination; Mercaptoacid; Microsome; Metabolism; In vitro; Kidney; Pig; Toxicokinetics; Vertebrata; Mammalia; Urinary system; Animal; Artiodactyla; Acetylation; Ungulata; Xenobiotic

N-Acetylation of xenobiotic-derived cysteine S-conjugates is a key step in the mercapturic acid pathway. The aim of this study was to investigate the N-acetylation of haloalkene-derived S-haloalkyl and S-haloalkenyl cysteine S-conjugates by porcine kidney cysteine S-conjugate N-acetyltransferase (NA...