Changes in size of motor axons in hereditary canine spinal muscular atrophy

• Published in: Laboratory investigation Vol. 61; no. 3; pp. 333 - 342
• Main Authors: CORK, L. C, STRUBLE, R. G, GOLD, B. G, DICARLO, C, FAHNESTOCK, K. E, GRIFFIN, J. W, PRICE, D. L
• Format: Journal Article
• Language: English
• Published: New York, NY Nature Publishing 01.09.1989
• Subjects: Age Factors; Animals; Atrophy - pathology; Axons - pathology; Biological and medical sciences; Dogs; Medical sciences; Motor Neurons - pathology; Muscular Atrophy, Spinal - genetics; Muscular Atrophy, Spinal - pathology; Myelin Sheath - pathology; Nervous system involvement in other diseases. Miscellaneous; Neurology; Phenotype; Fissipedia; Animal model; Carnivora; Nervous system diseases; Motor neuron disease; Axon; Exploration; Amyotrophic lateral sclerosis; Motor neuron; Genetic disease; Vertebrata; Mammalia; Newborn animal; Animal; Morphometry; Dog

Hereditary canine spinal muscular atrophy (HCSMA), a dominantly inherited disorder of motor neurons, has three phenotypes: accelerated, intermediate, and chronic. In the accelerated and intermediate phenotypes, axonal sizes in ventral roots were smaller than in controls. Reductions in axonal size oc...