Importance of decreased intracellular phosphate and magnesium concentrations and reduced ATPase activities in spontaneously hypertensive rats

• Published in: Magnesium research Vol. 13; no. 3; p. 183
• Main Authors: Kisters, K, Krefting, E R, Hausberg, M, Kohnert, K D, Honig, A, Bettin, D
• Format: Journal Article
• Language: English
• Published: England 01.09.2000
• Subjects: Adenosine Triphosphate - analysis; Animals; Aorta; Electron Probe Microanalysis; Hypertension - metabolism; Magnesium - analysis; Muscle, Smooth, Vascular - chemistry; Muscle, Smooth, Vascular - enzymology; Phosphates - analysis; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium-Potassium-Exchanging ATPase - metabolism

A decrease in total magnesium content is not a direct proof of a decreased magnesium ion concentration. It could reflect a phosphate alteration or an ATP metabolism disorder. Plasma phosphate levels are lower in spontaneously hypertensive rats (SHRs) than in Wistar-Kyoto (WKY) rats, and defects in m...