Propylene glycol monomethyl ether (PGME) occupational exposure. 1. Biomonitoring by analysis of PGME in urine

• Published in: International archives of occupational and environmental health Vol. 73; no. 5; pp. 311 - 315
• Main Authors: DEVANTHERY, A, DENTAN, A, BERODE, M, DROZ, P.-O
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.07.2000
• Subjects: Adult; Biological and medical sciences; Chemical and industrial products toxicology. Toxic occupational diseases; Chromatography, Gas; Environmental Monitoring - methods; Humans; Least-Squares Analysis; Male; Medical sciences; Occupational Exposure - analysis; Propylene Glycols - pharmacokinetics; Propylene Glycols - urine; Reference Values; Sensitivity and Specificity; Time Factors; Toxicology; Various organic compounds; Human; Urine; Gas chromatography; Biological fluid; Occupational exposure; Occupational medicine; Biological monitoring; Quantitative analysis

An analytical method was developed for the determination of free and conjugated PGME-alpha in urine. The method involves a solid-phase extraction on LC-18 columns and a GC/FID analysis after derivatization with trimethysilylimidazole. The assay was linear (least-squares regression coefficient 0.996)...