Loss of heterozygosity of TP53 is not correlated with clinicopathological variables in sporadic colorectal carcinomas

• Published in: Anticancer research Vol. 19; no. 2A; p. 1325
• Main Authors: González-Aguilera, J J, Herrero, M P, Maillo, C, Moreno-Azcoita, M, Fernández-Peralta, A M
• Format: Journal Article
• Language: English
• Published: Greece 01.03.1999
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Female; Genes, p53; Humans; Loss of Heterozygosity; Male; Middle Aged; Neoplasm Staging; Polymerase Chain Reaction

We have analyzed the loss of heterozygosity (LOH) of TP53 in a series of 96 sporadic colorectal carcinomas by means of PCR, using two microsatellite sequences (TP53 and Mfd152), to investigate its possible relationship with several clinicopathological variables in the Spanish population. Forty six o...