Serum bactericidal activity against Klebsiella pneumoniae in volunteers receiving increasing doses of tobramycin with or without cefamandole

• Published in: International journal of clinical pharmacology research Vol. 7; no. 1; p. 45
• Main Authors: Pascual-Lopez, A, Lagast, H, Klastersky, J
• Format: Journal Article
• Language: English
• Published: Switzerland 1987
• Subjects: Adult; Cefamandole - blood; Cefamandole - pharmacology; Drug Interactions; Drug Resistance, Microbial; Female; Humans; Klebsiella pneumoniae - drug effects; Male; Microbial Sensitivity Tests; Tobramycin - blood; Tobramycin - pharmacology

Ten volunteers received intravenously in a randomly allocated order and on separate days the following regimens: cefamandole (15 mg/kg); tobramycin (1.5 mg/kg); tobramycin (3 mg/kg); cefamandole (15 mg/kg) + tobramycin (1.5 mg/kg); cefamandole (15 mg/kg) + tobramycin (3 mg-kg). Tobramycin serum leve...