Chronic nitrosamine ingestion in 1040 rodents : the effect of the choice of nitrosamine, the species studied, and the age of starting exposure

• Published in: Cancer research (Chicago, Ill.) Vol. 51; no. 23; pp. 6470 - 6491
• Main Authors: GRAY, R, PETO, R, BRANTOM, P, GRASSO, P
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.12.1991
• Subjects: Age Factors; Animals; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - toxicity; Chemical agents; Cricetinae; Diethylnitrosamine - toxicity; Dimethylnitrosamine - toxicity; Esophageal Neoplasms - chemically induced; Liver Neoplasms, Experimental - chemically induced; Medical sciences; Mesocricetus; Mice; N-Nitrosopyrrolidine - toxicity; Nitrosamines - toxicity; Rats; Respiratory Tract Neoplasms - chemically induced; Sex Factors; Species Specificity; Tumors; Rat; Nitrosamine; Rodentia; Oral administration; Species specificity; Carcinogenesis; Long term; Site of action; Dose activity relation; Vertebrata; Mammalia; Animal; Age; Comparative study
• ISSN: 0008-5472

In parallel with a larger experiment on 4080 rats fed 16 different concentrations of N-nitrosodiethylamine (NDEA) or N-nitrosodimethylamine (NDMA) from 6 weeks of age, a variety of smaller experiments on a total of 1040 rodents were undertaken and are the subject of the present report. Three separat...