Genetic distinctions between types 1 and 2 autoimmune hepatitis

• Published in: The American journal of gastroenterology Vol. 92; no. 12; p. 2197
• Main Authors: Czaja, A J, Kruger, M, Santrach, P J, Moore, S B, Manns, M P
• Format: Journal Article
• Language: English
• Published: United States 01.12.1997
• Subjects: Adult; Alleles; DNA Primers; Female; Gene Frequency; Genetic Predisposition to Disease; Germany; Hepatitis, Autoimmune - classification; Hepatitis, Autoimmune - genetics; Hepatitis, Autoimmune - immunology; Histocompatibility Antigens Class II - genetics; HLA-DR Antigens - classification; HLA-DR Antigens - genetics; HLA-DRB1 Chains; Humans; Incidence; Male; Middle Aged; Polymerase Chain Reaction; Prevalence; Risk Factors; Sequence Analysis, DNA; United States; United States; Germany

Our aim was to determine whether alleles affecting susceptibility to type 1 autoimmune hepatitis in the United States occur as commonly in German patients with type 2 disease. DNA specimens from 12 German patients with type 2 autoimmune hepatitis were tested for class II alleles of the major histoco...