p53 gene product in pleural effusions. Practical use in distinguishing benign from malignant cells

• Published in: Acta cytologica Vol. 40; no. 5; p. 855
• Main Authors: Mullick, S S, Green, L K, Ramzy, I, Brown, R W, Smith, D, Gondo, M M, Cagle, P T
• Format: Journal Article
• Language: English
• Published: Switzerland 01.09.1996
• Subjects: Evaluation Studies as Topic; Female; Humans; Immunoenzyme Techniques; Male; Pleural Effusion, Malignant - diagnosis; Pleural Effusion, Malignant - pathology; Tumor Suppressor Protein p53 - analysis

To determine the utility of positive p53 immunostaining as an adjunct in the diagnosis of malignancy in pleural effusions, we reviewed 103 effusions representing the typical range of diagnoses encountered in the evaluation of pleural fluid cytology. Immunohistochemistry was performed on paraffin-emb...