Determining disease activity in inflammatory bowel disease
To provide a stronger relationship between clinical assessment of disease activity and laboratory measurements, we studied hemoglobin concentrations, sedimentation rates, and the serum levels of albumin and of seromucoids in 86 patients; first when seriously ill with either ulcerative colitis or Cro...
Saved in:
Published in | Journal of clinical gastroenterology Vol. 6; no. 1; p. 17 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
01.02.1984
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | To provide a stronger relationship between clinical assessment of disease activity and laboratory measurements, we studied hemoglobin concentrations, sedimentation rates, and the serum levels of albumin and of seromucoids in 86 patients; first when seriously ill with either ulcerative colitis or Crohn's disease, and then again when they were well. Only albumin and seromucoids were separated clearly in the two states: hemoglobin and sedimentation rates showed significant overlap. Paired correlation tests between 10 laboratory variables in 149 patients with Crohn's disease of varying severity revealed a highly significant correlation between seromucoids and albumin (r = 0.71). Both variables correlated with six others, but at lower levels. Processing the correlation matrix by factor analysis suggested that the serum levels of albumin and seromucoid are indicators of the same effect--disease activity. A simple index using only hemoglobin, albumin, and seromucoid values, was derived from this analysis, positive values indicating health and negative ill health. Serum levels of albumin and seromucoids provide the essential data to determine disease activity at routine follow-up of inflammatory bowel disease or to indicate the success or failure of therapeutic regimens, overriding any arbitrary clinical assessment. |
---|---|
AbstractList | To provide a stronger relationship between clinical assessment of disease activity and laboratory measurements, we studied hemoglobin concentrations, sedimentation rates, and the serum levels of albumin and of seromucoids in 86 patients; first when seriously ill with either ulcerative colitis or Crohn's disease, and then again when they were well. Only albumin and seromucoids were separated clearly in the two states: hemoglobin and sedimentation rates showed significant overlap. Paired correlation tests between 10 laboratory variables in 149 patients with Crohn's disease of varying severity revealed a highly significant correlation between seromucoids and albumin (r = 0.71). Both variables correlated with six others, but at lower levels. Processing the correlation matrix by factor analysis suggested that the serum levels of albumin and seromucoid are indicators of the same effect--disease activity. A simple index using only hemoglobin, albumin, and seromucoid values, was derived from this analysis, positive values indicating health and negative ill health. Serum levels of albumin and seromucoids provide the essential data to determine disease activity at routine follow-up of inflammatory bowel disease or to indicate the success or failure of therapeutic regimens, overriding any arbitrary clinical assessment. |
Author | Cooke, W T Prior, P |
Author_xml | – sequence: 1 givenname: W T surname: Cooke fullname: Cooke, W T – sequence: 2 givenname: P surname: Prior fullname: Prior, P |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6699391$$D View this record in MEDLINE/PubMed |
BookMark | eNo1j8tKAzEYRrOo1N4eQZgXGMitycSd1CsU3Oi65E_-SGSSGSZRmbe3YIUD3-bwwVmTRR4yLsiKMsNbqg29JutSPillWgi2JEuljBGGrcjtPVacUswxfzQ-FrQFG-tq_I51bmI-E3qbkq3DNDcw_GD_r23JVbB9wd1lN-T98eHt8NweX59eDnfHduRiX1sn0HaSak9BCeiMUcoyzYNHLhWnDDyC9FLshfaSucCcO6tCBehAgwK-ITd_v-MXJPSncYrJTvPp0sB_AR6IRGk |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine |
ExternalDocumentID | 6699391 |
Genre | Journal Article Comparative Study |
GroupedDBID | --- .-D .3C .GJ .XZ .Z2 0R~ 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 71W 8L- AAAAV AAHPQ AAIQE AAMTA AAQQT AARTV AASCR AAUEB AAWTL AAYEP ABASU ABBUW ABDIG ABJNI ABVCZ ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFO ACGFS ACILI ACNWC ACWDW ACWRI ACXJB ACXNZ ADFPA ADGGA ADHPY ADNKB AE3 AE6 AEETU AENEX AFDTB AFFNX AFSOK AFUWQ AGINI AHQNM AHRYX AHVBC AINUH AJIOK AJNWD AJNYG AJZMW ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BQLVK BS7 C45 CGR CS3 CUY CVF DIWNM DU5 DUNZO E.X EBS ECM EEVPB EIF EJD EX3 F2K F2L F5P FCALG FL- GNXGY GQDEL H0~ HLJTE HZ~ IKREB IN~ IPNFZ J5H JF9 JG8 JK3 JK8 K8S KD2 KMI L-C L7B N9A NPM N~M O9- OAG OAH OCUKA ODA OJAPA OL1 OLG OLV OLW OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVOZU OWBYB OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P R58 RIG RLZ RXW S4R S4S T8P TAF TEORI TSPGW V2I VVN W3M WOQ WOW X3V X3W XXN XYM YFH YOC ZFV ZGI ZXP ZZMQN |
ID | FETCH-LOGICAL-p235t-c3ea8407d0b63b89966a172fde246201bdeb4d43537d41cf1ccd0b36fb8b7b6b2 |
ISSN | 0192-0790 |
IngestDate | Sat Sep 28 07:33:11 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p235t-c3ea8407d0b63b89966a172fde246201bdeb4d43537d41cf1ccd0b36fb8b7b6b2 |
PMID | 6699391 |
ParticipantIDs | pubmed_primary_6699391 |
PublicationCentury | 1900 |
PublicationDate | 1984-Feb |
PublicationDateYYYYMMDD | 1984-02-01 |
PublicationDate_xml | – month: 02 year: 1984 text: 1984-Feb |
PublicationDecade | 1980 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Journal of clinical gastroenterology |
PublicationTitleAlternate | J Clin Gastroenterol |
PublicationYear | 1984 |
SSID | ssj0017331 |
Score | 1.4008912 |
Snippet | To provide a stronger relationship between clinical assessment of disease activity and laboratory measurements, we studied hemoglobin concentrations,... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 17 |
SubjectTerms | Adult Aged Blood Sedimentation Colitis - blood Colitis - diagnosis Colitis, Ulcerative - blood Colitis, Ulcerative - diagnosis Crohn Disease - blood Crohn Disease - diagnosis Erythrocyte Indices Female Health Status Indicators Hemoglobins - analysis Humans Male Middle Aged Orosomucoid - analysis Reference Values Serum Albumin - analysis Serum Globulins - analysis |
Title | Determining disease activity in inflammatory bowel disease |
URI | https://www.ncbi.nlm.nih.gov/pubmed/6699391 |
Volume | 6 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JS8NAFB6sovQibsWdHLxGmsx0kniTqhShpYcWeyt5MxPpoQs1IPjrfbOk6aKiXoYwMwnJ-5LJ9-ZthNywINZ_osAHGYHPBH6KkEZ1P1T1EM9RNDbe7u0Ob_XZ86AxKCuGmuiSHG7Fx5dxJf9BFfsQVx0l-wdkFxfFDjxGfLFFhLH9FcYPzpdFq_vO0mKSY5h6ECPtw5gh4GNrSIfpu1o1yGxy0kWc5Gv6ls-nOl_nfGXfvVlk6Hwpvau785HV-bvlFkKQxKzwOi53FY0Lqq3bWSyLfAN9u8TZUMsl6c7GRrycI9Wxlbd-HFxLb-1GKqQSxXqF6ujdFmcFKutJ2turkl03fU0JMGSgd0D2ncS8ewvJIdlSkyOy13Z-CsfkbgkZz4ncK5DxRhNvGRnPIFNMOyH9p8des-W7KhX-LKSN3BdUpaglR7IOnEKs9ccUWWEmVcg40iuQCphEVkojyQKRBULgVMoziCECDmGNbE-mE3VKvAiYSjSlkwkwHiepTAOhaBRIITPB6Bmp2acezmwqkqETx_l3AxekWgJ-SXYyfPPVFdKoHK6NrD8BFNQiBA |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Determining+disease+activity+in+inflammatory+bowel+disease&rft.jtitle=Journal+of+clinical+gastroenterology&rft.au=Cooke%2C+W+T&rft.au=Prior%2C+P&rft.date=1984-02-01&rft.issn=0192-0790&rft.volume=6&rft.issue=1&rft.spage=17&rft_id=info%3Apmid%2F6699391&rft_id=info%3Apmid%2F6699391&rft.externalDocID=6699391 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0192-0790&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0192-0790&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0192-0790&client=summon |