LDL receptor activity is down-regulated similarly by a cholesterol-containing diet high in palmitic acid or high in lauric and myristic acids in cynomolgus monkeys

• Published in: The Journal of nutrition Vol. 125; no. 8; pp. 2055 - 2063
• Main Authors: STUCCHI, A. F, TERPSTRA, A. H. M, NICOLOSI, R. J
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Nutritional Sciences 01.08.1995
• Subjects: Animals; Apolipoproteins B - metabolism; Biological and medical sciences; Cholesterol - blood; Cholesterol, Dietary - pharmacology; Diet; Down-Regulation - drug effects; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Lauric Acids - administration & dosage; Lauric Acids - pharmacology; Lipoproteins - blood; Macaca fascicularis; Male; Myristic Acids - administration & dosage; Myristic Acids - pharmacology; Palmitic Acids - administration & dosage; Palmitic Acids - pharmacology; Receptors, LDL - drug effects; Receptors, LDL - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Nutrition; Lauric acid; Monkey; Macaca fascicularis; Lipids; Cholesterol LDL; Metabolism; Palmitic acid; Feeding; Apolipoprotein B; Lipoprotein LDL; Vertebrata; Mammalia; Myristic acid; Saturated fatty acid; Primates; Simioidea; Catabolism; Biological receptor

To determine the mechanisms whereby diets differing widely in fatty acid composition affect plasma LDL cholesterol and apolipoprotein B concentrations, LDL kinetics and receptor- and nonreceptor-mediated LDL catabolism were investigated in 27 cynomolgus monkeys fed diets containing 0.05 mg cholester...