Pharmacokinetics of tiaprofenic acid in infants after a single oral dose

• Published in: International journal of clinical pharmacology and therapeutics Vol. 34; no. 8; p. 342
• Main Authors: Pariente-Khayat, A, Dubois, M C, Vauzelle-Kervroëdan, F, Rey, E, D'Athis, P, D'Yvoire, M B, Saint-Maurice, C, Olive, G, Pons, G
• Format: Journal Article
• Language: English
• Published: Germany 01.08.1996
• Subjects: Administration, Oral; Age Factors; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Child, Preschool; Female; Humans; Infant; Male; Minor Surgical Procedures; Propionates - administration & dosage; Propionates - pharmacokinetics

Ten healthy infants (15.2 +/- 10.6 months old, range 6-35) anesthetized for minor surgery were given a single oral dose (3 mg x kg-1) of tiaprofenic acid (TA). Seven venous blood samples and 0-12 h urine were collected. TA concentrations in plasma and urine were measured by HPLC. Within the whole gr...