Donor leukocyte transfusions and discontinuation of immunosuppressants to achieve an initial remission after allogeneic bone marrow transplantation in a patient with primary refractory acute leukemia

• Published in: Bone marrow transplantation (Basingstoke) Vol. 18; no. 1; pp. 257 - 261
• Main Authors: AZUNO, Y, KANEKO, T, KAMEI, S, ZAITSU, Y, TAKEUCHI, Y, OKA, Y, KAKU, K, NISHIMURA, M, OKUYA, S, NAKAI, K, NOMIYAMA, J, MORI, K, OKAFUJI, K, OKUBO, M, MATSUTANI, A
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.07.1996
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Bone Marrow - pathology; Bone Marrow Transplantation - immunology; Clone Cells - immunology; Clone Cells - pathology; Combined Modality Therapy; Drug Resistance, Neoplasm; Fatal Outcome; Female; Graft vs Host Disease - drug therapy; Graft vs Host Disease - etiology; Graft vs Host Reaction; Humans; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Leukocyte Transfusion; Male; Medical sciences; Methylprednisolone - administration & dosage; Methylprednisolone - adverse effects; Neoplastic Cells, Circulating; Neoplastic Stem Cells - immunology; Neoplastic Stem Cells - pathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Prednisolone - administration & dosage; Prednisolone - adverse effects; Recurrence; Remission Induction; Tissue Donors; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation, Homologous; Blood product; HLA-System; Discontinuous; Chemoprophylaxis; Transfusion; Leukocyte; Leukemia; Major histocompatibility system; Homograft; Prevention; Bone marrow; Graft; Remission; Mixed lineage; Human; Immunopathology; Acute; Related donor; Graft versus host reaction; Malignant hemopathy; Case study; Treatment; Young adult; Immunosuppressive agent; Histocompatibility

We present a female patient who received an allogeneic bone marrow transplantation for primary refractory Philadelphia-positive acute biphenotypic leukemia. Since leukemic blasts were persistently present in peripheral blood and bone marrow, in spite of the evidence for engraftment of male donor hem...