Donor leukocyte transfusions and discontinuation of immunosuppressants to achieve an initial remission after allogeneic bone marrow transplantation in a patient with primary refractory acute leukemia
We present a female patient who received an allogeneic bone marrow transplantation for primary refractory Philadelphia-positive acute biphenotypic leukemia. Since leukemic blasts were persistently present in peripheral blood and bone marrow, in spite of the evidence for engraftment of male donor hem...
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| Published in | Bone marrow transplantation (Basingstoke) Vol. 18; no. 1; pp. 257 - 261 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Basingstoke
Nature Publishing Group
01.07.1996
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| Subjects | |
| Online Access | Get full text |
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| Abstract | We present a female patient who received an allogeneic bone marrow transplantation for primary refractory Philadelphia-positive acute biphenotypic leukemia. Since leukemic blasts were persistently present in peripheral blood and bone marrow, in spite of the evidence for engraftment of male donor hematopoiesis, we performed donor leukocyte transfusions and discontinued immunosuppression. An initial complete remission was obtained 15 weeks after allogeneic bone marrow transplantation, and lasted for 24 weeks. We concluded that the prominent mechanism for the eradication of the refractory leukemic clone in the patient was the graft-versus-leukemia effect. |
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| AbstractList | We present a female patient who received an allogeneic bone marrow transplantation for primary refractory Philadelphia-positive acute biphenotypic leukemia. Since leukemic blasts were persistently present in peripheral blood and bone marrow, in spite of the evidence for engraftment of male donor hematopoiesis, we performed donor leukocyte transfusions and discontinued immunosuppression. An initial complete remission was obtained 15 weeks after allogeneic bone marrow transplantation, and lasted for 24 weeks. We concluded that the prominent mechanism for the eradication of the refractory leukemic clone in the patient was the graft-versus-leukemia effect. |
| Author | NISHIMURA, M ZAITSU, Y TAKEUCHI, Y KAMEI, S NOMIYAMA, J MORI, K KANEKO, T OKA, Y AZUNO, Y KAKU, K OKUBO, M OKAFUJI, K MATSUTANI, A NAKAI, K OKUYA, S |
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| Keywords | Blood product HLA-System Discontinuous Chemoprophylaxis Transfusion Leukocyte Leukemia Major histocompatibility system Homograft Prevention Bone marrow Graft Remission Mixed lineage Human Immunopathology Acute Related donor Graft versus host reaction Malignant hemopathy Case study Treatment Young adult Immunosuppressive agent Histocompatibility |
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| Snippet | We present a female patient who received an allogeneic bone marrow transplantation for primary refractory Philadelphia-positive acute biphenotypic leukemia.... |
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| SubjectTerms | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone Marrow - pathology Bone Marrow Transplantation - immunology Clone Cells - immunology Clone Cells - pathology Combined Modality Therapy Drug Resistance, Neoplasm Fatal Outcome Female Graft vs Host Disease - drug therapy Graft vs Host Disease - etiology Graft vs Host Reaction Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Leukocyte Transfusion Male Medical sciences Methylprednisolone - administration & dosage Methylprednisolone - adverse effects Neoplastic Cells, Circulating Neoplastic Stem Cells - immunology Neoplastic Stem Cells - pathology Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Prednisolone - administration & dosage Prednisolone - adverse effects Recurrence Remission Induction Tissue Donors Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation, Homologous |
| Title | Donor leukocyte transfusions and discontinuation of immunosuppressants to achieve an initial remission after allogeneic bone marrow transplantation in a patient with primary refractory acute leukemia |
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