Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine biosynthesis by α-difluoromethylornithine

• Published in: Cancer research (Chicago, Ill.) Vol. 43; no. 8; pp. 3732 - 3738
• Main Authors: TAKIGAWA, M, VERMA, A. K, SIMSIMAN, R. C, BOUTWELL, R. K
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.08.1983
• Subjects: Adenosylmethionine Decarboxylase - metabolism; Administration, Oral; Administration, Topical; Animals; Antineoplastic agents; Biological and medical sciences; Cell Division - drug effects; Chemotherapy; Eflornithine; Epidermis - drug effects; Epidermis - metabolism; Female; Injections, Intraperitoneal; Medical sciences; Mice; Ornithine - administration & dosage; Ornithine - analogs & derivatives; Ornithine - pharmacology; Ornithine Decarboxylase - metabolism; Pharmacology. Drug treatments; Polyamines - biosynthesis; Skin Neoplasms - chemically induced; Tetradecanoylphorbol Acetate; Antineoplastic agent; Skin disease; Polyamine; Intraperitoneal administration; Rodentia; Enzyme inhibitor; Epidermis; Biosynthesis; Ornithine decarboxylase; Vertebrata; Chemotherapy; Mammalia; Treatment; Mouse; Animal; Skin; Inhibition; Tumor promoter; Experimental tumor; Topical administration

Application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a manifold induction of ornithine decarboxylase (ODC) activity within 5 hr and an increased accumulation of putrescine. The relevance of these TPA-induced changes to the mechanism of tumor prom...