Mechanisms and clinical significance of cell volume regulation

• Published in: Nephrology, dialysis, transplantation Vol. 13; no. 4; pp. 867 - 874
• Main Authors: WALDEGGER, S, STEUER, S, RISLER, T, HEIDLAND, A, CAPASSO, G, MASSRY, S, LANG, F
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.04.1998
• Subjects: Animals; Apoptosis; Biological and medical sciences; Cell Division; Cell Size; Humans; Ion Transport; Kidney Diseases - pathology; Medical sciences; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Renal failure; Signal Transduction; Endocrinopathy; Kidney disease; Human; Urinary system disease; Pathogenesis; Diabetes mellitus; Ion transport; Hepatic disease; Metabolism; Mechanism; Liver failure; Regulation(control); Metabolic disorder; Renal failure; Example; Digestive diseases; Molecular biology; Uremia; Cell volume
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/13.4.867

A wide variety of factors challenge constancy of cell volume. Alterations of cell volume activate diverse cell volume regulatory mechanisms including ion transport, osmolyte accumulation, metabolism and expression of appropriate genes. A wealth of cellular signalling pathways link cell volume to the respective regulatory mechanisms. Cell volume emerges as a pathophysiologically important parameter in several diseases including diabetes mellitus, uraemia, hepatic insufficiency and hypercatabolic states. The role of altered cell volume in disease is a challenge which requires more experimental research and clinical investigation.