Characterization of clofazimine metabolites in humans by HPLC-electrospray mass spectrometry

Clofazimine (CAS 2030-63-9) is an important drug used in the treatment of leprosy. Its important metabolites are investigated by thin layer chromatography (TLC), HPLC (diode array) and HPLC-electrospray mass spectrometry. The resulting analytical data, extraction, isolation and characterization meth...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 47; no. 3; p. 303
Main Authors Krishna, D R, Mamidi, R N, Hofmann, U, Prabhakar, C M
Format Journal Article
LanguageEnglish
Published Germany 01.03.1997
Subjects
Adult
Biotransformation
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Clofazimine - pharmacokinetics
Clofazimine - urine
Humans
Leprostatic Agents - pharmacokinetics
Leprostatic Agents - urine
Liver - enzymology
Male
Mass Spectrometry
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Summary:Clofazimine (CAS 2030-63-9) is an important drug used in the treatment of leprosy. Its important metabolites are investigated by thin layer chromatography (TLC), HPLC (diode array) and HPLC-electrospray mass spectrometry. The resulting analytical data, extraction, isolation and characterization methods are presented. Their applicability is described for human urine analysis.
ISSN:0004-4172