Imbalance in the nucleotide pools of myeloid leukemia cells and HL-60 cells: correlation with cell-cycle phase, proliferation, differentiation, and transformation

• Published in: Cancer research (Chicago, Ill.) Vol. 47; no. 7; pp. 1841 - 1847
• Main Authors: DE KORTE, D, HAVERKORT, W. A, DE BOER, M, VAN GENNIP, A. H, ROOS, D
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.04.1987
• Subjects: Biological and medical sciences; Cell Cycle; Cell Differentiation; Cell Division; Cell Line; Cell Transformation, Neoplastic; Hematologic and hematopoietic diseases; Humans; Kinetics; Leukemia, Myeloid - metabolism; Leukemia, Myeloid, Acute - metabolism; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Nucleotides - metabolism; Human; Promyelocytic leukemia; Cell culture; Induction; Hemopathy; Blast transformation; Cell differentiation; Metabolism; Cell transformation; Pyrimidine; Cell cycle; Chronic myelocytic leukemia; Nucleotide; Purine; Tumor cell

Myeloblasts from the blood of patients with chronic myeloid leukemia (CML) in a blastoid crisis were shown to have an imbalance in the ribonucleotide pools compared with normal blood neutrophils. This imbalance includes decreased ratios of purine:pyrimidine, adenine:guanine, and uracil:cytosine nucl...