Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts

• Published in: Transplantation Vol. 66; no. 11; p. 1439
• Main Authors: Ierino, F L, Kozlowski, T, Siegel, J B, Shimizu, A, Colvin, R B, Banerjee, P T, Cooper, D K, Cosimi, A B, Bach, F H, Sachs, D H, Robson, S C
• Format: Journal Article
• Language: English
• Published: United States 15.12.1998
• Subjects: Animals; Complement Activation; Complement System Proteins - analysis; Disseminated Intravascular Coagulation - complications; Fibrin Fibrinogen Degradation Products - metabolism; Fibrinogen - metabolism; Fibrinolysis - physiology; Graft Rejection - complications; Kidney - pathology; Kidney Transplantation - immunology; Microscopy, Electron; Papio; Swine; Transplantation Conditioning; Transplantation, Heterologous

Intravascular fibrin deposition and platelet sequestration occur with porcine xenograft rejection by baboons. Disseminated intravascular coagulopathy may arise either as a direct consequence of the failure to fully deplete xenoreactive natural antibodies and block complement, or because of putative...