The pharmacokinetics of pranlukast in healthy young and elderly subjects

• Published in: International journal of clinical pharmacology and therapeutics Vol. 34; no. 9; p. 375
• Main Authors: Brocks, D R, Upward, J, Hust, R, Köester, F E, Collie, H, Qian, Y, Dennis, M J
• Format: Journal Article
• Language: English
• Published: Germany 01.09.1996
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Asthma - drug therapy; Asthma - metabolism; Chromones - blood; Chromones - pharmacokinetics; Female; Humans; Male

Pranlukast is a novel LTD4 antagonist under development for the treatment of asthma. To assess the effect of age, the pharmacokinetics of pranlukast were studied in healthy young (9 females, 10 males, mean 30 years) and elderly subjects (9 per sex, mean 70.4 years). After an overnight fast volunteer...