Production of abnormal prothrombin (des-γ-carboxyprothrombin) by hepatocellular carcinoma: a clinical experimental study

• Published in: Journal of hepatology Vol. 4; no. 3; pp. 357 - 363
• Main Authors: OKUDA, H, OBATA, H, NAKANISHI, T, FURUKAWA, R, HASHIMOTO, E
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier 01.06.1987
• Subjects: Biological and medical sciences; Biomarkers; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - metabolism; Cell Line; Digestive System Neoplasms - blood; Female; Gastroenterology. Liver. Pancreas. Abdomen; Hepatitis - blood; Hepatitis, Chronic - blood; Humans; Liver Cirrhosis - blood; Liver Neoplasms - blood; Liver Neoplasms - metabolism; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Pregnancy; Protein Precursors; Prothrombin - analogs & derivatives; Prothrombin - biosynthesis; Prothrombin - blood; Tumors; Human; Liver cell carcinoma; Liver; Prothrombin; Digestive diseases; Tumor; Anomaly; Blood plasma

We measured plasma abnormal prothrombin (des-gamma-carboxy prothrombin; DCP) levels in normal subjects and in patients with hepatocellular carcinoma and other various diseases using the enzyme-linked immunosorbent assay developed by Motohara et al. (Pediatr Res 1985; 19: 354-357). Fifty-eight percen...