Basic fibroblast growth factor overexpression in endothelial cells : an autocrine mechanism for angiogenesis and angioproliferative diseases

• Published in: Cell growth & differentiation Vol. 7; no. 2; pp. 147 - 160
• Main Authors: GUALANDRIS, A, RUSNATI, M, ZICHE, M, CORALLINI, A, POSSATI, L, VACCA, A, RIBATTI, D, PRESTA, M, BELLERI, M, NELLI, E. E, BASTAKI, M, MOLINARI-TOSATTI, M. P, BONARDI, F, PAROLINI, S, ALBINI, A, MORBIDELLI, L
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.02.1996
• Subjects: 3T3 Cells - cytology; 3T3 Cells - physiology; Animals; Aorta - cytology; Biological and medical sciences; Cell physiology; Cell Size - drug effects; Cell Size - physiology; Cell Transformation, Viral; Chick Embryo; Collagen - pharmacology; DNA, Complementary - genetics; Drug Combinations; Endothelium, Corneal - cytology; Endothelium, Vascular - cytology; Endothelium, Vascular - physiology; Endothelium, Vascular - ultrastructure; Extracellular Matrix; Fibrin - pharmacology; Fibroblast Growth Factor 2 - physiology; Fundamental and applied biological sciences. Psychology; Humans; Injections, Intravenous; Laminin - pharmacology; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron; Molecular and cellular biology; Neovascularization, Pathologic - physiopathology; Ovum - ultrastructure; Proteoglycans - pharmacology; Rabbits; Responses to growth factors, tumor promotors, other factors; Retroviridae - genetics; Angiogenesis; In vivo; Autocrine secretion; Endothelial cell; Polypeptide; Animal; Gene overexpression; Basic fibroblast growth factor; Neovascularization; In vitro

Basic fibroblast growth factor (bFGF) is expressed in vascular endothelium during tumor neovascularization and angioproliferative diseases. The ultimate significance of this observation is poorly understood. We have investigated the biological consequences of endothelial cell activation by endogenou...