Hepatoprotective activity of 1-ethoxysilatrane and 1-isopropoxygermatrane

1-Ethoxysilatrane and 1-isopropoxygermatrane stimulated liver regeneration via activation of some components of the protein-synthesizing complex, in particular, aminoacyl-tRNA synthetases. Acylating activity of aminoacyl-tRNA synthetases increased. Possible mechanisms of these changes are discussed.

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Published inBulletin of experimental biology and medicine Vol. 134; no. 4; pp. 342 - 344
Main Authors Voronkov, M G, Nurbekov, M K, Rasulov, M M
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.10.2002
Subjects
Amino Acyl-tRNA Synthetases - metabolism
Animals
Bridged Bicyclo Compounds, Heterocyclic - pharmacology
Cell Division - drug effects
Cell Size - drug effects
Dose-Response Relationship, Drug
Enzyme Activation
Germanium - pharmacology
Kinetics
Liver - cytology
Liver - enzymology
Liver - metabolism
Liver Regeneration
Male
Mitosis - drug effects
Mitotic Index
Nitriles - pharmacology
Organometallic Compounds - pharmacology
Organosilicon Compounds - pharmacology
Protein Biosynthesis
Rats
Substrate Specificity
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Abstract 1-Ethoxysilatrane and 1-isopropoxygermatrane stimulated liver regeneration via activation of some components of the protein-synthesizing complex, in particular, aminoacyl-tRNA synthetases. Acylating activity of aminoacyl-tRNA synthetases increased. Possible mechanisms of these changes are discussed.
AbstractList 1-Ethoxysilatrane and 1-isopropoxygermatrane stimulated liver regeneration via activation of some components of the protein-synthesizing complex, in particular, aminoacyl-tRNA synthetases. Acylating activity of aminoacyl-tRNA synthetases increased. Possible mechanisms of these changes are discussed.
Author Rasulov, M M
Voronkov, M G
Nurbekov, M K
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SubjectTerms Amino Acyl-tRNA Synthetases - metabolism
Animals
Bridged Bicyclo Compounds, Heterocyclic - pharmacology
Cell Division - drug effects
Cell Size - drug effects
Dose-Response Relationship, Drug
Enzyme Activation
Germanium - pharmacology
Kinetics
Liver - cytology
Liver - enzymology
Liver - metabolism
Liver Regeneration
Male
Mitosis - drug effects
Mitotic Index
Nitriles - pharmacology
Organometallic Compounds - pharmacology
Organosilicon Compounds - pharmacology
Protein Biosynthesis
Rats
Substrate Specificity
Title Hepatoprotective activity of 1-ethoxysilatrane and 1-isopropoxygermatrane
URI https://www.ncbi.nlm.nih.gov/pubmed/12533754
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