Synthesis and diversity analysis of lead discovery piperazine-2-carboxamide libraries

• Published in: Molecular diversity Vol. 4; no. 4; pp. 221 - 232
• Main Authors: Herpin, T F, Morton, G C, Dunn, A K, Fillon, C, Menard, P R, Tang, S Y, Salvino, J M, Labaudinière, R F
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.01.1998
• Subjects: Chemical synthesis; Combinatorial Chemistry Techniques; Pharmacology; Piperazines - chemical synthesis

A Lead Discovery Library of piperazine-2-carboxamide derivatives was produced for general screening. This paper discloses two novel solid phase synthetic routes used to produce 15,000 single compounds via the Irori directed sorting technique. Computational methods such as reagent clustering and libr...