Mass Spectrometry-Based Proteomics Technologies to Define Endogenous Protein-Protein Interactions and Their Applications to Cancer and Viral Infectious Diseases

• Published in: Mass spectrometry reviews
• Main Authors: Yu, Clinton, Adavikolanu, Rithika, Kaake, Robyn M, Huang, Lan
• Format: Journal Article
• Language: English
• Published: United States 09.02.2025
• Subjects: Proximity Labeling Mass Spectrometry (PL‐MS); protein‐protein interactions (PPIs); virology; Co‐Fractionation Mass Spectrometry (CF‐MS); Cross‐Linking Mass Spectrometry (XL‐MS); protein footprinting; genome tagging; immunoprecipitation (IP); Affinity Purification Mass Spectrometry (AP‐MS); Cancer

An intricate network of protein assemblies and protein-protein interactions (PPIs) underlies nearly every biological process in living systems. The organization of these cellular networks is highly dynamic and intimately tied to the genomic and proteomic landscapes of a cell. Disruptions in normal P...