Abnormal co-enzymatic behavior of a one-electron reduced bipyridinium salt with a carbamoyl group on the catalytic activity of CO2 reduction by formate dehydrogenase

• Published in: New journal of chemistry Vol. 42; no. 19; pp. 15556 - 1556
• Main Authors: Ikeyama, S, Amao, Y
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 2018
• Subjects: Carbon dioxide; Catalysis; Catalytic activity; Dehydrogenases; Enzymes; Formate dehydrogenase; Formic acid; Reduction
• DOI: 10.1039/c8nj03478h
• ISSN: 1144-0546

One-electron reduced bipyridinium salt (BP&z.rad;) acts as a co-enzyme for formate dehydrogenase (FDH) from Candida boidinii in CO 2 reduction to formic acid. By using BP&z.rad; with a carbamoyl group (CMV&z.rad;), the CO 2 reduction catalytic activity of FDH was improved compared with those of other BP&z.rad;s. Moreover, CMV&z.rad; did not act as a co-enzyme for FDH in the presence of more than 20 times higher concentration of CMV&z.rad; against FDH. This is the first report of BP&z.rad; with the abnormal co-enzymatic behavior on the catalytic activity of CO 2 reduction by FDH. A carbamoyl-modified bipyridinium salt has an enhancement and deactivation behaviour on the catalytic activity of CO 2 reduction by formate dehydrogenase (FDH) from Candida boidinii .