Human soluble tumor necrosis factor receptor I (sTNF-RI) and interleukin-I receptor antagonist (IL-I Ra) in different stages of acute rheumatic fever
Acute rheumatic fever (ARF) results from an autoimmune response to infection with group A streptococci. Serum concentrations of two anti-inflammatory cytokines, interleukin-I receptor antagonist (IL-IRa) and human soluble tumor necrosis factor receptor I (sTNF-RI) were determined in patients with AR...
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Published in | Anadolu kardiyoloji dergisi : AKD Vol. 8; no. 2; pp. 139 - 142 |
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Aves Yayıncılık
01.04.2008
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Abstract | Acute rheumatic fever (ARF) results from an autoimmune response to infection with group A streptococci. Serum concentrations of two anti-inflammatory cytokines, interleukin-I receptor antagonist (IL-IRa) and human soluble tumor necrosis factor receptor I (sTNF-RI) were determined in patients with ARF at the time of admission and 3 months after treatment in order to evaluate changes in cytokine concentrations occurring during different stages of the disease.
Serum concentrations of two anti-inflammatory cytokines, IL-I Ra and sTNF-RI , were investigated in children with ARF at the time of admission (n=21) and after 3 months following the cessation of treatment (n=15). The sTNF-RI and sIL-IRa were measured quantitatively in serum using enzyme-linked immunosorbent assay (ELISA).
Levels of IL-1Ra and sTNF-RI were found to be significantly higher during acute phase and remission period of ARF when compared to age-matched healthy controls (p=0.001 and p=0.0001, respectively).
Our study demonstrated that two anti-inflammatory cytokines, serum sTNFRI and IL-1Ra, are increased in acute and remission stages of ARF reflecting activation of the cellular immune response. We suggest this increase might probably be generated in an effort to counteract the already increased concentrations of proinflammatory cytokines. |
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AbstractList | OBJECTIVEAcute rheumatic fever (ARF) results from an autoimmune response to infection with group A streptococci. Serum concentrations of two anti-inflammatory cytokines, interleukin-I receptor antagonist (IL-IRa) and human soluble tumor necrosis factor receptor I (sTNF-RI) were determined in patients with ARF at the time of admission and 3 months after treatment in order to evaluate changes in cytokine concentrations occurring during different stages of the disease.METHODSSerum concentrations of two anti-inflammatory cytokines, IL-I Ra and sTNF-RI , were investigated in children with ARF at the time of admission (n=21) and after 3 months following the cessation of treatment (n=15). The sTNF-RI and sIL-IRa were measured quantitatively in serum using enzyme-linked immunosorbent assay (ELISA).RESULTSLevels of IL-1Ra and sTNF-RI were found to be significantly higher during acute phase and remission period of ARF when compared to age-matched healthy controls (p=0.001 and p=0.0001, respectively).CONCLUSIONOur study demonstrated that two anti-inflammatory cytokines, serum sTNFRI and IL-1Ra, are increased in acute and remission stages of ARF reflecting activation of the cellular immune response. We suggest this increase might probably be generated in an effort to counteract the already increased concentrations of proinflammatory cytokines. Acute rheumatic fever (ARF) results from an autoimmune response to infection with group A streptococci. Serum concentrations of two anti-inflammatory cytokines, interleukin-I receptor antagonist (IL-IRa) and human soluble tumor necrosis factor receptor I (sTNF-RI) were determined in patients with ARF at the time of admission and 3 months after treatment in order to evaluate changes in cytokine concentrations occurring during different stages of the disease. Serum concentrations of two anti-inflammatory cytokines, IL-I Ra and sTNF-RI , were investigated in children with ARF at the time of admission (n=21) and after 3 months following the cessation of treatment (n=15). The sTNF-RI and sIL-IRa were measured quantitatively in serum using enzyme-linked immunosorbent assay (ELISA). Levels of IL-1Ra and sTNF-RI were found to be significantly higher during acute phase and remission period of ARF when compared to age-matched healthy controls (p=0.001 and p=0.0001, respectively). Our study demonstrated that two anti-inflammatory cytokines, serum sTNFRI and IL-1Ra, are increased in acute and remission stages of ARF reflecting activation of the cellular immune response. We suggest this increase might probably be generated in an effort to counteract the already increased concentrations of proinflammatory cytokines. Akut romatizmal ateş (ARA) grup A streptokoklara karşı otoimmun yanıt sonucu gelişir. Bu çalışmada ARA tanılı olgularda, iki antiinflamatuvar sitokin olan interlökin-I reseptör antagonist (IL-IRa) ve solubl tümör nekrosis faktör reseptör I (sTNF-RI) düzeyleri tanı anında ve tedavi başlandıktan 3 ay sonra ölçülerek hastalığın değişik evrelerindeki sitokin konsantrasyonlarındaki değişikliğin saptanması amaçlanmıştır. Yöntemler: Serum IL-IRa ve sTNF-RI düzeyleri ARA tanılı olgularda tanı anında (n=21) ve tedavi başladıktan 3 ay sonra (n=15) değerlendirilmiştir. Serum sTNF-RI, sIL-IRa konsantrasyonları kantitatif olarak ELISA metodu ile ile ölçülmüştür. Bulgular: Serum IL-1Ra ve sTNF-RI düzeyleri ARA tanılı olgularda hem akut dönemde hem de remisyonda yaş uyumlu sağlıklı kontrol grubuna göre anlamlı yüksek bulunmuştur (p=0.001 ve p=0.0001). Sonuç: Akut romatizmal ateşte serum sTNFRI ve IL-1Ra düzeylerindeki hem akut, hem de remisyon dönemlerindeki artış sellüler immün yanıttaki aktivasyonu göstermektedir. Antiinflamatuvar sitokin düzeylerindeki bu artış akut romatizmal ateşte aynı zamanda artmış bulunan proinflamatuvar sitokin konsantrasyonuna karşı dengeyi sağlamak amacı ile olabilir.(Anadolu Kardiyol Derg 2008; 8: 139-42) Acute rheumatic fever (ARF) results from an autoimmune response to infection with group A streptococci. Serum concentrations of two anti-inflammatory cytokines, interleukin-I receptor antagonist (IL-IRa) and human soluble tumor necrosis factor receptor I (sTNF-RI) were determined in patients with ARF at the time of admission and 3 months after treatment in order to evaluate changes in cytokine concentrations occurring during different stages of the disease. Methods: Serum concentrations of two anti-inflammatory cytokines, IL-I Ra and sTNF-RI , were investigated in children with ARF at the time of admission (n=21) and after 3 months following the cessation of treatment (n=15). The sTNF-RI and sIL-IRa were measured quantitatively in serum using enzyme-linked immunosorbent assay (ELISA). Results: Levels of IL-1Ra and sTNF-RI were found to be significantly higher during acute phase and remission period of ARF when compared to age-matched healthy controls (p=0.001 and p=0.0001, respectively). Conclusion: Our study demonstrated that two anti-inflammatory cytokines, serum sTNFRI and IL-1Ra, are increased in acute and remission stages of ARF reflecting activation of the cellular immune response. We suggest this increase might probably be generated in an effort to counteract the already increased concentrations of proinflammatory cytokines. |
Author | Karaca, Neslihan E Kurugöl, Zafer Sözeri, Betül Y Koturoğlu, Güldane Aksu, Güzide Ozyürek, Ruhi A Kütükçüler, Necil |
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Snippet | Acute rheumatic fever (ARF) results from an autoimmune response to infection with group A streptococci. Serum concentrations of two anti-inflammatory... OBJECTIVEAcute rheumatic fever (ARF) results from an autoimmune response to infection with group A streptococci. Serum concentrations of two anti-inflammatory... Akut romatizmal ateş (ARA) grup A streptokoklara karşı otoimmun yanıt sonucu gelişir. Bu çalışmada ARA tanılı olgularda, iki antiinflamatuvar sitokin olan... |
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SubjectTerms | Acute Disease Akut hastalık Bacterial infections and mycoses Bakteriyel enfeksiyonlar ve mikozlar Cardiovascular diseases Case-Control Studies Child Female Hastalık şiddeti belirtileri Humans Kardiyovasküler hastalıklar Male Receptors, Interleukin-1 Receptors, Interleukin-1 - antagonists & inhibitors Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type I - blood Reseptörler, interlökin-1 Reseptörler, tümör nekroz faktör, tip I Rheumatic Heart Disease Rheumatic Heart Disease - blood Rheumatic Heart Disease - immunology Rheumatic Heart Disease - pathology Romatizmal kalp hastalığı Severity of Illness Index |
Title | Human soluble tumor necrosis factor receptor I (sTNF-RI) and interleukin-I receptor antagonist (IL-I Ra) in different stages of acute rheumatic fever |
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