The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA

• Published in: Nucleic acids research Vol. 43; no. 10; pp. 5182 - 5193
• Main Authors: Segalla, Simona, Pivetti, Silvia, Todoerti, Katia, Chudzik, Malgorzata Agata, Giuliani, Erica Claudia, Lazzaro, Federico, Volta, Viviana, Lazarevic, Dejan, Musco, Giovanna, Muzi-Falconi, Marco, Neri, Antonino, Biffo, Stefano, Tonon, Giovanni
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 26.05.2015
• Subjects: Animals; Cell Line; DNA-Binding Proteins - metabolism; Exosome Multienzyme Ribonuclease Complex - metabolism; Humans; Mice; MicroRNAs - metabolism; RNA; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism

Multiple myeloma, the second most frequent hematologic tumor after lymphomas, is an incurable cancer. Recent sequencing efforts have identified the ribonuclease DIS3 as one of the most frequently mutated genes in this disease. DIS3 represents the catalytic subunit of the exosome, a macromolecular co...