Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity - Freudenberg, Johannes M; Ghosh, Swati; Lackford, Brad L; Yellaboina, Sailu; Zheng, Xiaofeng; Li, Ruifang; Cuddapah, Suresh; Wade, Paul A; Hu, Guang; Jothi, Raja (Nucleic acids research, 2012)
Keywords: 5-Methylcytosine - analogs & derivatives; Animals; Cells, Cultured; Chromatin; Cytosine - analogs & derivatives; Cytosine - metabolism; Data processing; Demethylation; Differentiation; DNA; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA Methyltransferase 3B; DNA-Binding Proteins - antagonists & inhibitors; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Embryo cells; Embryonic Stem Cells - cytology; Embryonic Stem Cells - enzymology; Embryonic Stem Cells - metabolism; Enzymes; Extracellular signal-regulated kinase; Gene Expression Profiling; Gene Expression Regulation; Gene Regulation, Chromatin and Epigenetics; genomics; Homeodomain Proteins - metabolism; Leukemia inhibitory factor; Leukemia Inhibitory Factor - metabolism; MAP kinase; MAP Kinase Signaling System; Mice; Nanog Homeobox Protein; Proto-Oncogene Proteins - antagonists & inhibitors; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - physiology; Reviews; RNA Interference; Signal Transduction; Stat3 protein; STAT3 Transcription Factor - metabolism; Stem cells; Transcription activation